Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum

@article{Glick1994EffectsOI,
  title={Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum},
  author={Stanley D. Glick and Martin E. Kuehne and John Raucci and Thomas E. Wilson and Danielle Larson and Richard W. Keller and Jeffrey N. Carlson},
  journal={Brain Research},
  year={1994},
  volume={657},
  pages={14-22}
}
Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addiction to opioid and stimulant drugs and has been reported to decrease morphine and cocaine self-administration in rats. The present study sought to determine if other iboga alkaloids, as well as the chemically related harmala alkaloid harmaline, would also reduce the intravenous self-administration of morphine and cocaine in rats. Because both ibogaine and harmaline induce tremors, an effect that may be… Expand
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TLDR
Noribogaine (40 mg/kg) was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and striatum, similar to effects previously observed with ibogaine. Expand
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Ibogaine's excitatory effect on VTA neurons is not long-lasting nor does it persistently alter cocaine- or morphine-induced changes in dopamine neuron impulse activity, so other mechanisms must be explored to account for the proposed antiaddictive properties of ibogaine. Expand
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The serotonergic system may not be an essential factor in the anti-addictive actions of these drugs; ibogaine (or an unidentified metabolite) may release serotonin as well as inhibit its reuptake; stimulation of the ascending seroton allergic system may mediate ibogane's hallucinogenic effect; and 18-MC probably has no affinity for the serotonin transporter, and is unlikely to be a hallucinogen. Expand
Ibogaine and Cocaine Abuse: Pharmacological Interactions at Dopamine and Serotonin Receptors
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In vitro perfusion studies have proven a useful model to study the effect of ibogaine on neurotransmitter systems and the functional effects of such interactions and the potential importance of its action on serotonergic modulation of dopamine release. Expand
Comparative neurobiological effects of ibogaine and MK-801 in rats.
TLDR
The present findings show that the effects of ibogaine on DA neurotransmission and neuroendocrine secretion are not fully mimicked by MK-801, indicating that the wide spectrum of in vivo actions of Ibogaine can probably not be explained simply on the basis of antagonism at NMDA receptors. Expand
Mechanisms of Antiaddictive Actions of Ibogaine a
TLDR
The authors' ongoing studies in rats suggest that kappa agonist and NMDA antagonist actions contribute to ibogaine's effects on opioid and stimulant self‐administration, while the serotonergic actions may be more important for ibogane‐induced decreases in alcohol intake. Expand
Interactions between iboga agents and methamphetamine sensitization: studies of locomotion and stereotypy in rats
TLDR
Iboga agents augment both the locomotor and stereotypic effects of METH in a manner consistent with previous reports for cocaine, suggesting that iboga agents interact in a similar manner with the neural mechanisms mediating motor hyperactivity induced by the chronic administration of stimulant drugs. Expand
In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats.
TLDR
The present findings demonstrate that noribogaine is biologically active and undoubtedly contributes to the in vivo pharmacological profile of ibogaine in rats and appears less apt to produce the adverse effects associated with ibogain, indicating the metabolite may be a safer alternative for medication development. Expand
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