Effects of hypoxia on renin secretion and renal renin gene expression.

@article{Kraemer1998EffectsOH,
  title={Effects of hypoxia on renin secretion and renal renin gene expression.},
  author={Bernhard Kraemer and Theresia Ritthaler and Frank Schweda and Frieder K Kees and Karin Schricker and Stephan R. Holmer and Armin Kurtz},
  journal={Kidney international. Supplement},
  year={1998},
  volume={67},
  pages={S155-8}
}
Plasma renin activity (PRA) and renal renin mRNA levels were measured in male rats exposed to hypoxia (8% O2) or to carbon monoxide (CO; 0.1%) for six hours. PRA increased fourfold and 3.3-fold, and renin mRNA levels increased to 220% and 200% of control, respectively. In primary cultures of renal juxtaglomerular (JG) cells, hypoxia (lowering medium O2 from… CONTINUE READING