Effects of hypoxia on color vision with emphasis on the mesopic range

  title={Effects of hypoxia on color vision with emphasis on the mesopic range},
  author={John L. Barbur and Desmond M. Connolly},
  journal={Expert Review of Ophthalmology},
  pages={409 - 420}
The ability to see clear images, to resolve fine spatial detail in faint objects, to see and appreciate small color differences, to discriminate motion direction and to detect rapidly flickering lights over a very large range of natural illumination is something we often take for granted. Good vision is our expectation, but as we grow older, we become aware of very gradual visual deficits that in some cases can lead to severe loss of vision. These deficits are often caused by changes in the… 

Spatial and temporal aspects of visual performance in relation to light level and normal aging

Three studies designed to investigate the ability of the observer to detect stimuli defined by changes in luminance in space and/or time in mesopic conditions demonstrate that the detection of luminance defined stimuli can be compromised in a number of external conditions such as low light levels, as well as due to internal changes caused by aging to the optics of the eye, retina and/ or the central visual system.

Color vision in the twilight zone: an unsolved problem

Color vision under mesopic conditions warrants further examination, with particular attention to hypoxia as an important confound in high-terrain, aviation, and aerospace applications.

Changes in color vision with decreasing light level: separating the effects of normal aging from disease.

The purpose of this study was to obtain additional information about the health of the retina by measuring the rate of loss of chromatic sensitivity with decreasing light level, and to screen for preclinical signs of retinal disease.

Effects of Acute Hypoxia on Early Visual and Auditory Evoked Potentials

Results suggest that early sensory processing is not impaired during hypoxia, but for the auditory system there is impairment at the level of attentional processing, and this impairment does not stem from early visual processing deficits in visual cortex.

Detection of Early Loss of Color Vision in Age-Related Macular Degeneration - With Emphasis on Drusen and Reticular Pseudodrusen.

The anatomic integrity of cone photoreceptors remains relatively unaffected in early and intermediate stages of AMD, but the processing of cone signals in the retina can, however, be heavily disrupted with subsequent loss of both YB and RG chromatic sensitivity.

Acuity and colour vision changes post intravitreal dexamethasone implant injection in patients with diabetic macular oedema

RG colour thresholds provide a sensitive measure of functional change in diabetic subjects with macular oedema and suggest that the improvement in the RG chromatic sensitivity can provide a useful biomarker for monitoring the efficacy of treatment in DMO.

Occupational colour vision needs with emphasis on aviation

With appropriate design and choice of colours, it is possible for deutan applicants with thresholds < 4 standard normal CAD units to perform as well as normal trichromats when suprathreshold colours with RG and YB components are employed in visual displays.

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During the assessment of the visual detection distance of transgenic Danio rerio larvae in response to a visual stimulus using selective plane illumination microscopy, it is found that the distance is shorter at elevated temperatures.

Colour vision in diabetes

The results from this study show that the magnitude of chromatic sensitivity losses correlates with the severity of diabetic retinopathy, but the correlation with factors, normally associated with high risk of diabetes is low.

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Mild hypoxia impairs chromatic sensitivity in the mesopic range.

The CAD test revealed minimal deuteranomaly (R-G deficiency) in the man and loss of Y-B sensitivity in the only woman using hormonal contraception and mild hypoxia impairs chromatic sensitivity progressively with reducing luminance.

Low contrast acuity at photopic and mesopic luminance under mild hypoxia, normoxia, and hyperoxia.

Mild hypoxia degrades low contrast acuity progressively with decreasing mesopic luminance, implying that visual performance is oxygen-dependent in the mid-mesopic range, and supplementary oxygen enhances low Contrast Acuity.

Oxygenation State and Mesopic Sensitivity to Dynamic Contrast Stimuli

  • D. ConnollyS. Hosking
  • Medicine
    Optometry and vision science : official publication of the American Academy of Optometry
  • 2009
Temperature-dependent changes in mesopic sensitivity are greater than expected from altered retinal illumination alone and support outer retinal (photoreceptor) susceptibility to hypoxia under twilight viewing, suggesting oxygen-dependent performance.

The effect of a moderate level of hypoxia on human color vision

It is concluded that studies evaluating man's visual performance at altitude must consider post-receptoral processes, as hypoxia acts by depressing retinal ganglion cell activity and that it can affect photopic visual processes as well as scotopic vision.

Oxygenation state and twilight vision at 2438 m.

  • D. Connolly
  • Medicine
    Aviation, space, and environmental medicine
  • 2011
The results indicate that twilight vision may be susceptible to conditions of altered oxygenation at upper-to-mid mesopic luminance with relevance to contemporary night flying, including using night vision devices.

Modification of colour vision in the green/red axis in acute and chronic hypoxia explored with a portable anomaloscope.

The effects of acute, subacute, and chronic altitude hypoxia on colour vision in the green/red axis were explored in eight sea-level natives by means of a simple portable anomaloscope and the influence of factors such as fatigue, season, and age is discussed.

Effects of light and darkness on oxygen distribution and consumption in the cat retina

Fits of the profiles to a one-dimensional model of oxygen diffusion indicated that light reduced the oxygen consumption of the outer retina to approximately 50% of its dark-adapted value.

Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration

It is argued that at the macula stressed retinal neurons adapt during development to a limited blood supply from the choriocapillaris, which supplies little in excess of metabolic demand of the neural retina under normal conditions.

Measurements of chromatic sensitivity in the mesopic range

We measured chromatic threshold sensitivity in the mesopic range using a combination of techniques that mask the detection of photopic and scotopic luminance contrast signals. The measurements were

Effect of dysoxia and moderate air-hyperbarism on red-green color sensitivity.

In general, during moderate air-hyperbarism and HBO2 color vision seems to be normal, but evaluation of the colored scene is probably less stable and slightly slower.