Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.

  title={Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.},
  author={Kazuya Nakashima and Michael M. Todd},
  volume={27 5},
BACKGROUND AND PURPOSE Hypothermia slows the increase in extracellular excitatory amino acid (EAA) concentrations during temporary cerebral ischemia. However, it is unclear whether hypothermia slows the rate of EAA release or just delays the time until the first sharp increase (which occurs coincident with terminal depolarization). METHODS Pericranial temperatures were adjusted to 38 degrees C, 34 degrees C, 31 degrees C, or 25 degrees C in halothane-anesthetized rats. The cortical DC voltage… CONTINUE READING


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