Effects of hypothermia on oligodendrocyte precursor cell proliferation, differentiation and maturation following hypoxia ischemia in vivo and in vitro.

@article{Xiong2013EffectsOH,
  title={Effects of hypothermia on oligodendrocyte precursor cell proliferation, differentiation and maturation following hypoxia ischemia in vivo and in vitro.},
  author={Man Xiong and Jin Li and Si-Min Ma and Yi Yang and Wenhao Zhou},
  journal={Experimental neurology},
  year={2013},
  volume={247},
  pages={720-9}
}
Hypoxic-ischemia (HI) not only causes gray matter injury but also white matter injury, leading to severe neurological deficits and mortality, and only limited therapies exist. The white matter of animal models and human patients with HI-induced brain injury contains increased oligodendrocyte precursor cells (OPCs). However, little OPC can survive and mature to repair the injured white matter. Here, we test the effects of mild hypothermia on OPC proliferation, differentiation and maturation… CONTINUE READING
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