Effects of hypothermia on ex vivo microglial production of pro- and anti-inflammatory cytokines and nitric oxide in hypoxic-ischemic brain-injured mice.

Abstract

INTRODUCTION Activated microglia produce neurotoxic factors, including pro-inflammatory cytokines and nitric oxide (NO), in response to neuronal destruction. Therapeutic suppression of microglial release of these factors by various approaches including hypothermia is considered to be neuroprotective after severe brain damage. We examined the effects of… (More)

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@article{Matsui2014EffectsOH, title={Effects of hypothermia on ex vivo microglial production of pro- and anti-inflammatory cytokines and nitric oxide in hypoxic-ischemic brain-injured mice.}, author={Tomohiro Matsui and Hiroyuki Kida and Takuya Iha and Tabito Obara and Sadahiro Nomura and Tatsuya Fujimiya and Michiyasu Suzuki}, journal={Folia neuropathologica}, year={2014}, volume={52 2}, pages={151-8} }