Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver.

@article{Shimazu1975EffectsOH,
  title={Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver.},
  author={Takashi Shimazu and Sachiko Ogasawara},
  journal={The American journal of physiology},
  year={1975},
  volume={228 6},
  pages={1787-93}
}
Hypothalamic effects on gluconeogenesis and glycosis in rat liver were studied byelectrical stimulations of the ventromedial hypothalamic nucleus (LH) without disturbing the animal's behavior. Stimulation of VMH caused a increase in the activity of phosphoenolpyruvate carboxykinase (PEPCK), a key gluconeogenic enzyme, and marked suppression of pyruvate kinase (PK), a key glycolytic enzyme, of the liver. Stimulationof LH, on the other hand, resulted in a decrease in PEPCK activity but did not… CONTINUE READING
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