Effects of hypothalamic and preoptic lesions on reproductive behavior in male rats

@article{Christensen1977EffectsOH,
  title={Effects of hypothalamic and preoptic lesions on reproductive behavior in male rats},
  author={Larry W. Christensen and Dwight M. Nance and Roger A. Gorski},
  journal={Brain Research Bulletin},
  year={1977},
  volume={2},
  pages={137-141}
}
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116 Citations
Highly Influential Citations
2
Background Citations
21
Methods Citations
3
Results Citations
2

116 Citations

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Citation Type

Role of septum and preoptic area in regulating masculine and feminine sexual behavior in male rats
Effects of sexual behavioral manipulation on brain plasticity in adult rats
Recovery of masculine copulatory behavior from lesions of the medial preoptic area: effects of age versus hormonal state.
TLDR
The results of these experiments suggest that the plasticity (with respect to copulation) of the neural system encompassing the MPOA is a function of some aspect of chronological age unrelated to the animal's developmental hormonal condition prior to the time of the lesion.
Rostral midbrain lesions and copulatory behavior in male rats
Acceleration of mounting behaviors in female rats by ibotenic acid lesions in the ventromedial hypothalamic nucleus
P‐chlorophenylallanine Facilitates Copulatory Behavior in Septal Lesioned but not in Preoptic Lesioned Male Rats
TLDR
The results agreed with previous reports that both the medial preoptic area and the lateral septum play an excitatory role in regulating male sexual behavior and suggest that the inhibitory function of serotonergic neurons govern dependently on the function of the medial Preoptic Area, but independently on thefunction of the lateral Septum.
Potentiation of ejaculatory activity by median raphe nucleus lesions in male rats: effect of p-chlorophenylalanine.
TLDR
Results suggest that serotonergic neurons in the median raphe nucleus play an inhibitory role in the regulation of male sexual activity, especially ejaculation, and it can be thought that PCPA acts on the Median raphe neurons and facilitates ejaculatory behavior.
Effects of lesions of the sexually dimorphic nucleus on sexual behavior of testosterone-treated female wistar rats
Potentiation of Ejaculatory Activity by Nucleus Lesions in Male Rats: Effect of p-Chlorophenylalanine Median Raphe
TLDR
Results suggest that serotonergic neurons in the median raphe nucleus play an inhibitory role in the regulation of male sexual activity, especially ejaculation, and it can be thought that PCPA acts on the Median raphe neurons and facilitates ejaculatory behavior.
Effect of medullary raphe lesions on sexual behavior in male rats with or without treatments of p-chlorophenylalanine
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References

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Modifications in gonadotropin control and reproductive behavior in the female rat by hypothalamic and preoptic lesions
Intrahypothalamic implants of testosterone or estradiol and resumption of masculine sexual behavior in long-term castrated male rats.
TLDR
When tested for masculine sexual behavior 7, 10 and 13 days after the start of steroid treatment, animals receiving testosterone applications in the POA exhibited significantly more mounts, intromissions and ejaculations than the animals receivingosterone in the PHA or cholesterol in the preoptic area.
Examination of some factors that control the effects of septal lesions on lordosis behavior
Disruption of copulation in male rats after hypothalamic lesions: a behavioral, anatomical and neurochemical analysis.
Impairment of mating behavior in male rats following lesions in the preoptic-anterior hypothalamic continuum
Facilitation of female sexual behavior in male rats by septal lesions: An interaction with estrogen
Activation of the male rat's sexual behavior by intracerebral implantation of androgen.
TLDR
It was found that intracerebral implantation of testosterone could result in reappearance of the complete pattern of male sexual behavior in the absence of any histologically demonstrable stimulation of the seminal vesicles or prostate.
Lateral hypothalamic syndrome in rats: a comparison of the behavioral and neurochemical effects of lesions placed in the lateral hypothalamus and nigrostriatal bundle.
TLDR
This aspect of the lateral hypothalamic syndrome results from destruction of a small portion of theateral diencephalon and may be related to the interruption of the dopaminergic mesolimbic system.
Sexual Receptivity: Facilitation by Medial Preoptic Lesions in Female Rats
Lesions in the medial preoptic area of ovariectomized female rats reduced the quantity of estrogen needed to induce sexual receptivity in these animals. In addition, the number of days over which…
Autoradiographic Localization of Radioactivity in Rat Brain after Injection of Tritiated Sex Hormones
TLDR
In all brains, the preoptic area, prepiriform cortex, olfactory tubercle, and septum had particularly high, long-lasting uptake of both hormones.
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