Effects of hypertrophy on regional action potential characteristics in the rat left ventricle: a cellular basis for T-wave inversion?

@article{Shipsey1997EffectsOH,
  title={Effects of hypertrophy on regional action potential characteristics in the rat left ventricle: a cellular basis for T-wave inversion?},
  author={S J Shipsey and Simon M Bryant and George F. Hart},
  journal={Circulation},
  year={1997},
  volume={96 6},
  pages={2061-8}
}
BACKGROUND In cardiac hypertrophy, ECG T-wave changes imply an abnormal sequence of ventricular repolarization. We investigated the hypothesis that this is due to changes in the normal regional differences in action potential duration. We assessed the contribution of potassium- and calcium-dependent currents to these differences. Both the altered sequence of ventricular repolarization and the underlying cellular mechanisms may contribute to the increased incidence of ventricular arrhythmias in… CONTINUE READING