Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model

@inproceedings{Dostl2015EffectsOH,
  title={Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model},
  author={Pavel Dost{\'a}l and Jitka Schreiberov{\'a} and Vlasta Dostalova and Tomas Tyll and Jiř{\'i} P{\'a}ral and Islam Saleh Abdo and Miroslav Cihlo and David Astapenko and Zdeněk Turek},
  booktitle={BMC anesthesiology},
  year={2015}
}
BACKGROUND Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model. METHODS Rabbits (weight, 2.0-3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive… CONTINUE READING