Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain.

@article{Sarkisian1999EffectsOH,
  title={Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain.},
  author={Matthew R. Sarkisian and Gregory L. Holmes and Lionel Carmant and Zhao Liu and Yili Yang and Carl E Stafstrom},
  journal={Brain & development},
  year={1999},
  volume={21 5},
  pages={318-25}
}
Whether febrile seizures lead to hippocampal necrosis is a question of paramount clinical importance. This study attempted to simulate a complex febrile seizure, compared with hyperthermia (HYP) alone and prolonged seizure alone (produced by continuous hippocampal stimulation (CHS)). Four groups of rats were studied at each of two ages, immature (postnatal day, P20) and adult (P60). Group 1 was subjected to 45 min of HYP (body temperature 40 degrees C) plus CHS, Group 2 received 45 min of HYP… CONTINUE READING