Effects of hyperosmolality on calcium mobilization in renal inner medulla: relationship to alterations in prostaglandin E synthesis.


Hypertonic NaCl and mannitol stimulate the release of [14C]arachidonate and iPGE from rat inner medullary slices, whereas hypertonic urea suppresses these same parameters. Since numerous observations indicate that arachidonate release and PG synthesis in this tissue are Ca2+-dependent processes, we examined the possibility that the divergent actions of… (More)