Effects of hyperglycemia on function of isolated mouse pancreatic islets transplanted under kidney capsule.

@article{Korsgren1989EffectsOH,
  title={Effects of hyperglycemia on function of isolated mouse pancreatic islets transplanted under kidney capsule.},
  author={Olle Korsgren and Leif Jansson and Arne Andersson},
  journal={Diabetes},
  year={1989},
  volume={38 4},
  pages={
          510-5
        }
}
The insulin release from isolated pancreatic islets grafted under the kidney capsule was examined by means of a modified kidney-perfusion technique. The grafts, consisting of 150 C57BL/6 or 250 C57BL/Ks mouse islets, were implanted syngeneically under the left kidney capsule of normoglycemic or alloxan-induced diabetic recipients 4 wk before the perfusion. In both mouse strains, islets grafted to normoglycemic animals showed an immediate distinct peak of insulin release when challenged with… CONTINUE READING

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