Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis.

@article{Kellum2004EffectsOH,
  title={Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis.},
  author={John A. Kellum and Mingchen Song and Ramesh Venkataraman},
  journal={Chest},
  year={2004},
  volume={125 1},
  pages={243-8}
}
STUDY OBJECTIVE To determine the effects of hyperchloremic acidosis, induced by dilute HCl infusion, on BP and circulating inflammatory mediators in an experimental model of severe sepsis in the rat. DESIGN Randomized, open-label, controlled experiment. SETTING University research laboratory. PARTICIPANTS Twenty-four adult, male, Sprague-Dawley rats. INTERVENTION Eighteen hours after inducing lethal sepsis by cecal ligation and puncture, animals were randomized and classified into three… CONTINUE READING
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Effects of acidosis on LPS-mediated production of inflammatory cytokine and nitric oxide in RAW macrophages [abstract

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