Effects of hyper- and hypothyroidism on thyroid hormone concentrations in regions of the rat brain.

@article{Broedel2003EffectsOH,
  title={Effects of hyper- and hypothyroidism on thyroid hormone concentrations in regions of the rat brain.},
  author={Oliver Broedel and Murat Eravci and Sandra Fuxius and Tina Smolarz and Andreas Jeitner and Hannah Grau and Gisela Stoltenburg-Didinger and Hanna Plueckhan and Harald Meinhold and Andreas Baumgartner},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={285 3},
  pages={E470-80}
}
The purpose of this study was to investigate the effects of hyper- and hypothyroidism on thyroid hormone concentrations and deiodinase activities in nine regions of the rat brain. Four weeks of treatment with 75 microg thyroxine (T4)/kg body wt induced a two- to threefold increase in T4 levels in all of these brain regions, whereas the 3,5,3'-triiodothyronine (T3) concentrations were reduced in five brain regions and remained unchanged in four. Even after 8 wk treatment with 300 microg T4/kg… CONTINUE READING