Effects of hydroxytyrosol and hydroxytyrosol acetate administration to rats on platelet function compared to acetylsalicylic acid.

@article{GonzlezCorrea2008EffectsOH,
  title={Effects of hydroxytyrosol and hydroxytyrosol acetate administration to rats on platelet function compared to acetylsalicylic acid.},
  author={Jos{\'e} Antonio Gonz{\'a}lez-Correa and Mar{\'i}a Navas and Javier Mu{\~n}oz-Mar{\'i}n and Mariana Trujillo and Juan Fern{\'a}ndez-Bola{\~n}os and Jos{\'e} Pedro De La Cruz},
  journal={Journal of agricultural and food chemistry},
  year={2008},
  volume={56 17},
  pages={
          7872-6
        }
}
Virgin olive oil (VOO) contains the polyphenols hydroxytyrosol (HT) and hydroxytyrosol acetate (HT-AC). This study investigated the antiplatelet effect of HT and HT-AC in healthy rats and compared their effects to acetylsalicylic acid (ASA). All compounds were administered orally for 7 days. HT and HT-AC inhibited platelet aggregation in whole blood, with a 50% inhibitory dose (ID50) of 48.25 mg/kg per day for HT, 16.05 mg/kg per day for HT-AC, and 2.42 mg/kg per day for ASA. Platelet synthesis… 
Hydroxytyrosyl alkyl ether derivatives inhibit platelet activation after oral administration to rats.
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