Effects of hydrogen gas on exhausted CD8+ T cells (PD-1-positive, terminally differentiated CD8+ T cells).

@article{Akagi2017EffectsOH,
  title={Effects of hydrogen gas on exhausted CD8+ T cells (PD-1-positive, terminally differentiated CD8+ T cells).},
  author={J. Akagi and H. Baba},
  journal={Journal of Clinical Oncology},
  year={2017},
  volume={35}
}
e23071Background: CD8+ T cells progress from an early-differentiated (early-CD8+ T cells) to a terminally differentiated state (terminal-CD8+ T cells). PD-1 expression is rapidly upregulated in antigen-activated T cells, and rapidly downregulated when the antigen is cleared. In the presence of persistent antigen stimulation, such as that in cancer patients, PD-1 expression is not downregulated and terminal-CD8+T cells become exhausted. Methods: Using flow cytometry, we investigated PD-1… Expand

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