Effects of hydroflumethiazide in congestive heart failure: renal electrolyte excretion related to urinary thiazide excretion and aldosterone.

  title={Effects of hydroflumethiazide in congestive heart failure: renal electrolyte excretion related to urinary thiazide excretion and aldosterone.},
  author={O. Br{\o}rs and E. Enger and S. Jacobsen and A. Aakvaag and O. P. Foss},
  journal={Acta pharmacologica et toxicologica},
  volume={49 5},
The effect of hydroflumethiazide (HFT) on renal excretion of sodium, chloride, and potassium was studied in congestive heart failure and related to urinary excretion of thiazide and aldosterone. HFT 75 or 150 mg was administered orally once daily for 4 days to 8 male patients with roentgenological evidence of enlarged heart and slight or no peripheral oedema receiving digitalis and controlled diet. Urinary excretion of HFT did not change after repeated doses, whereas urinary excretion of a… Expand
1 Citations
Thiazides and loop-diuretics therapeutic aspects.
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  • Medicine
  • Acta medica Scandinavica. Supplementum
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The possibility of loop-diuretic induced osteopenia cannot be ruled out, which should be considered when choosing between thiazides and loop- diuretics for the treatment of mild to moderate CHF. Expand


Effect of repeated doses of hydroflumethiazide on renal excretion of electrolytes and uric acid in healthy subjects.
In the state of fluid deficiency and elevated aldosterone concentration, there was a significant positive correlation between log excretion rate of HFT and excretion Rate of sodium (r=0.68, P less than 0.001) but was probably influenced by other factors as well. Expand
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Evidence suggests that the therapeutic efficiency of a single dose of hydrochlorothiazide may be enhanced by the simple expedient of prescribing in the afternoon, and the word 'circadian' is not found in classical pharmacological texts although many examples of circadian-mediated drug action have now been described. Expand
Five Years' Experience with the Evaluation of Diuretic Agents
The large standard errors of the means for natriuresis, kaluresis and acute weight loss reflect the inherent biologic variation of such assays and permit separation of drugs into only a few overlapping categories of potency. Expand
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Blood pressure in normal and hypertensive subjects shows circadian variability with the minima during the hours of sleep, in particular, plasma and urinary aldosterone, plasma deoxycorticosterone and urinary sodium. Expand
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  • Medicine
  • Annals of the New York Academy of Sciences
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The large number of currently available diuretics has presented the practicing physician with a bewildering array of claims, facts, figures, and reports. These demand that he either spend much timeExpand
Quantitative fluorometric TLC procedure for determination of hydroflumethiazide in biological fluids,.
A rapid, sensitive, and specific fluorometric TLC procedure for the estimation of hydroflumethiazide in human biological fluids is described, and a mean recovery value of 99.7% was obtained when the drug was extracted from spiked human plasma samples, while 97.5% of drug was recovered from spikedhuman urine samples. Expand
Aromatic sulphamyl compounds with diuretic action.