Effects of 1-[(2-thiazolin-2-yl)amino]acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) on liver regeneration and function of hepatic mitochondria in partially hepatectomized rats.

  title={Effects of 1-[(2-thiazolin-2-yl)amino]acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) on liver regeneration and function of hepatic mitochondria in partially hepatectomized rats.},
  author={I Yoshitake and Eiko Ohishi and Kazuhiro Kubo},
  journal={Journal of pharmacobio-dynamics},
  volume={15 1},
Effects of 1-[(2-Thiazolin-2-yl)amino]acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363), a hepatoprotective compound, on liver regeneration, liver nucleic acid levels, mitochondrial respiration activity and hepatic energy metabolism after partial hepatectomy (OPE) in rats were studied. The liver regeneration rate was significantly increased in rats administered 100 mg/kg of KF-14363 for 6 d as compared with the control group administered… 
2 Citations

[Overview of 40 years' chemical study].

  • T. Imanishi
  • Chemistry, Biology
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2009
1,6-Dihydro-3(2H)-pyridinone, designed as a common synthon for synthesis of various natural products, was found to be easily prepared in large scale and successfully used to synthesize a variety of

Present status of hepatoprotectants.

  • V. RamA. Goel
  • Biology, Medicine
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1999
This review is an attempt to provide an overall view of the development of synthetic and natural products as hepatoprotective agents in the management of hepatic disorders.



Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.

The results demonstrate that KF-14363 is a compound that has a protective effect against the damage induced in various experimental liver injury models with different mechanisms.

[Effects of TJN-101, a lignan compound isolated from Schisandra fruits, on liver fibrosis and on liver regeneration after partial hepatectomy in rats with chronic liver injury induced by CCl4].

The results suggest that TJN-101 suppresses the fibrosis proliferation and accelerates both the liver regeneration and the recovery of liver function after partial hepatectomy in chronic liver injury.

Activation of mitochondrial functions by malotilate in relation to accelerated liver regeneration in partially hepatectomized rats.

It is supposed that malotilate activates the mitochondrial functions which results in the increases of ATP concentration and adenylate energy charge which can be associated with accelerated regeneration of the liver by malotILate.

Further characterization of a model of chronic endotoxemia in the rat: adenine nucleotide content in liver.

The energy status of the liver during endotoxemia cannot account for metabolic disturbances associated with this pathophysiological state and a decrease of ATP content paralleled by an increased level of ADP and AMP and by a fall of energy charge were seen when compared to acutely saline-injected rats.

[A comparative study of Laennec by intravenous or subcutaneous injection on CCl4-induced acute or chronic liver injury in rats].

Both intravenous and subcutaneous injections of Laennec minimized the pathological changes of the liver by CCl4 such as vacuolation, necrosis and swelling of nuclei, but did not inhibit the formation of pseudolobules.

Effect of single and repeated scalding on adenine nucleotides concentration in rat liver.

The results suggest that the energy state of the liver is related to the severity of a single scald, that the EC at the moment of repeating the scald is important for survival, and that the changes in ATP, EC, and TAN following a repeated scald are qualitatively or quantitatively different from those after a singleScald.


  • N. Bucher
  • Biology
    International review of cytology
  • 1963

Regeneration of liver in rats in the absence of portal splanchnic organs and a portal blood supply.

In rats, as previously demonstrated in dogs, evisceration does not prevent hepatic regeneration, and the hepatic artery alone is capable of supporting active liver cell proliferation, so it now seems open to question whether so-called portal blood hepatotrophic factors are the primary regulators of liver regeneration.