Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay.

@article{Jones2008EffectsOH,
  title={Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay.},
  author={M. E. Jones and Alexander H. Peden and Darren J. Wight and Christopher V. Prowse and Ian R Macgregor and Jean C Manson and Marc L. Turner and James W Ironside and Mark W Head},
  journal={Neuroreport},
  year={2008},
  volume={19 18},
  pages={1783-6}
}
Prion protein type and codon 129 genotype are thought to be major determinants of susceptibility and phenotype in human prion diseases. Using an in-vitro system (protein misfolding cyclic amplification) we have attempted to model human prion protein conversion using the abnormal prion protein associated with each of the major sporadic Creutzfeldt-Jakob disease subtypes, in substrates containing the normal cellular form of the prion protein of each of the three possible human PRNP codon 129… CONTINUE READING