Effects of host-dependent glycosylation of hemagglutinin on receptor-binding properties on H1N1 human influenza A virus grown in MDCK cells and in embryonated eggs.

@article{Gambaryan1998EffectsOH,
  title={Effects of host-dependent glycosylation of hemagglutinin on receptor-binding properties on H1N1 human influenza A virus grown in MDCK cells and in embryonated eggs.},
  author={Alexandra S. Gambaryan and V. P. Marinina and Alexander B. Tuzikov and Nicolai V. Bovin and Irina A. Rudneva and B. V. Sinitsyn and Aleksandr A. Shilov and Mikhail Matrosovich},
  journal={Virology},
  year={1998},
  volume={247 2},
  pages={170-7}
}
There is growing evidence that the receptor-binding characteristics of influenza viruses are affected by the host-dependent glycosylation of viral hemagglutinin (HA). To better understand these effects, we propagated two variants of the human influenza virus USSR/90/77 (which differed by the mutation Asn131 reversible Asp131 in the glycosylation sequon of their HA) in either embryonated chicken eggs or MDCK cell. Those variants were then compared for their ability to bind soluble receptor… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…