Effects of hormone replacement therapy on insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-1 to IGFBP-4: implications for cardiovascular risk.

@article{Heald2005EffectsOH,
  title={Effects of hormone replacement therapy on insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-1 to IGFBP-4: implications for cardiovascular risk.},
  author={Adrian H Heald and Kalpana Kaushal and Simon Anderson and Mark Redpath and Paul N. Durrington and Peter Selby and Martin Gibson},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  year={2005},
  volume={20 3},
  pages={176-82}
}
OBJECTIVE Hormone replacement therapy (HRT) in postmenopausal women is controversial, with an elevated cardiovascular event rate for combined estrogen-progestogen but no adverse cardiovascular effect and possible cumulative benefit for estrogen alone. Here we measured the effects of differing estrogen/progestogen combinations on the insulin-like growth factor (IGF)/IGF binding protein (IGFBP) system which has been implicated in the pathophysiological mechanisms underlying cardiovascular disease… CONTINUE READING

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