Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface.

@article{Yamamoto2000EffectsOH,
  title={Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface.},
  author={Masayuki Yamamoto and Hirokazu Hara and Tetsuo Adachi},
  journal={FEBS letters},
  year={2000},
  volume={486 2},
  pages={159-62}
}
Homocysteine is known to be a risk factor for several vascular diseases. Previously, we found a significant association between plasma homocysteine and plasma extracellular-superoxide dismutase (EC-SOD) levels. The binding of EC-SOD to human and bovine aortic endothelial cell cultures showed significant decreases after incubation with 10 microM homocysteine, whereas the expression of EC-SOD in fibroblast cell cultures was inhibited with a high concentration (1 mM) of homocysteine. Furthermore… CONTINUE READING
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