Effects of histidine and imidazolelactic acid on various parameters of the oxidative stress in cerebral cortex of young rats

@article{Tansini2004EffectsOH,
  title={Effects of histidine and imidazolelactic acid on various parameters of the oxidative stress in cerebral cortex of young rats},
  author={C. M Tansini and Karina Durigon and C. G Testa and Adriane Bell{\'o}-Klein and C. S Dutra-Filho},
  journal={International Journal of Developmental Neuroscience},
  year={2004},
  volume={22},
  pages={67-72}
}
Histidinemia is an inherited metabolic disorder caused by deficiency of histidase activity, which leads to tissue accumulation of histidine and its derivatives. Affected patients usually present with speech delay and mental retardation, although asymptomatic patients have been reported. Considering that the pathophysiology of the neurological dysfunction of histidinemia is not yet understood and since histidine has been considered a pro-oxidant agent, in the present study we investigated the… CONTINUE READING

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