Effects of histamine and related compounds on regional cerebral blood flow in rats.

@article{Suzuki1999EffectsOH,
  title={Effects of histamine and related compounds on regional cerebral blood flow in rats.},
  author={Guy Carrin Francois Diop David Dror Anil Gumber Willia Suzuki and Zhong Chen and Yukio Sugimoto and Yoko Fujii and Chiaki Kamei},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1999},
  volume={21 9},
  pages={613-7}
}
The effects of histamine and related compounds on regional cerebral blood flow (rCBF) in the hippocampus of conscious rats were studied. Intracerebroventricular injection of histamine caused a dose-dependent increase in rCBF in the hippocampus, and similar findings were observed with not only the H1 agonist, 2-thiazolylethylamine, but also the H2 agonist, dimaprit. Intraperitoneal injection of L-histidine also resulted in an increase in rCBF in the hippocampus, in parallel with elevation of… CONTINUE READING

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