Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.

@article{Adami2012EffectsOH,
  title={Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.},
  author={Maristella Adami and C Pozzoli and Alessandro Menozzi and Simone Bertini and Benedetta Passeri and A. Cantoni and Rogier A. Smits and Iwan J.P. de Esch and Rob Leurs and Gabriella Coruzzi},
  journal={Pharmacology},
  year={2012},
  volume={89 5-6},
  pages={287-94}
}
AIM In the present study we examined whether histamine H(4) receptors (H(4)Rs) have a role in gastric ulcerogenesis using a mouse model of gastric damage. METHODS The H(4)R antagonist JNJ7777120 and the H(4)R agonists VUF8430 and VUF10460 were investigated in fasted CD-1 mice against the ulcerogenic effect induced by co-administration of indomethacin(IND, 30 mg/kg s.c.) and bethanechol (BET, 5 mg/kg i.p.). Both macroscopic and histologic lesions were examined. Strain-related differences were… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…