Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats.

@article{Masuoka2007EffectsOH,
  title={Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats.},
  author={Takayoshi Masuoka and Azusa Mikami and Masa Yasuda and K A - NEDO Shinomiya and Chiaki Kamei},
  journal={European journal of pharmacology},
  year={2007},
  volume={576 1-3},
  pages={77-82}
}
The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at doses of 10 and 20 mg/kg, and a significant increase was also observed in reference memory errors at a dose of 20 mg/kg. Diphenhydramine and chlorphenilamine at a dose of 20 mg/kg… CONTINUE READING