Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study

@article{Forceville2007EffectsOH,
  title={Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study},
  author={Xavier Forceville and Bruno Laviolle and Djillali Annane and Dominique Vitoux and G{\'e}rard Bleichner and J. M. Korach and Emmanuel Cantais and Hugues Georges and J L Soubirou and Alain Combes and Eric Bellissant},
  journal={Critical Care},
  year={2007},
  volume={11},
  pages={R73 - R73}
}
INTRODUCTION Sepsis is associated with the generation of oxygen free radicals and (lacking) decreased selenium plasma concentrations. High doses of sodium selenite might reduce inflammation by a direct pro-oxidative effect and may increase antioxidant cell capacities by selenium incorporation into selenoenzymes. We investigated the effects of a continuous administration of high doses of selenium in septic shock patients. METHODS A prospective, multicentre, placebo-controlled, randomized… CONTINUE READING
47 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Selenium toxicity in animals with emphasis on man

  • OE Olson
  • J Am Coll Toxicol
  • 1986
Highly Influential
4 Excerpts

parative toxicosis of sodium selenite and selenomethionine in lambs

  • A Favier
  • J Vet Diagn Invest
  • 2006

Similar Papers

Loading similar papers…