Effects of high-dose methamphetamine on monoamine uptake sites in rat brain measured by quantitative autoradiography.

@article{Brunswick1992EffectsOH,
  title={Effects of high-dose methamphetamine on monoamine uptake sites in rat brain measured by quantitative autoradiography.},
  author={David J. Brunswick and Saloua Benmansour and Shanaz M. Tejani-Butt and Mirosława Hauptmann},
  journal={Synapse},
  year={1992},
  volume={11 4},
  pages={
          287-93
        }
}
The neurotoxicity of methamphetamine to monoaminergic neurons was examined. Neurotoxicity was assessed by quantitative autoradiography using radioligands specific for binding to norepinephrine, dopamine, and serotonin uptake sites. High-dose administration of methamphetamine led to decreases in binding to uptake sites for the three monoamines. Norepinephrine binding sites were decreased in certain amygdaloid nuclei and in the dorsomedial hypothalamic nucleus. Serotonin binding sites were… CONTINUE READING

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