• Corpus ID: 38211261

Effects of higenamine on isolated heart adrenoceptor of rabbit.

  title={Effects of higenamine on isolated heart adrenoceptor of rabbit.},
  author={C. W. Park and K. C. Chang and J. K. Lim},
  journal={Archives internationales de pharmacodynamie et de therapie},
  volume={267 2},
In the present study, effects of higenamine on various mechanical parameters of rabbit left atria as influenced by propranolol were investigated and compared to those of epinephrine. The following results are obtained: Higenamine, in a dose-dependent manner, increased the rate of tension development and shortened both the time to peak tension and the total duration of contraction. These effects of higenamine were competitively blocked by propranolol. The pA2 values of higenamine and epinephrine… 
Effects of Higenamine on the Contractility of Aorta and Taenia Coli in Guinea-pigs'
The inhibitory effects of higenamine on the spontaneous contractions of guineapig taenia coli result from the decrease of burst frequency and spike frequency through the P-adrenoceptors, which might be produced by the depression of intracellular Ca2+ mobilization and Ca2-influx through P- adrenOceptors in guinea-pig aorta.
Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria.
Results indicate that higenamine is a beta 1-adrenoceptor full agonist in murine atria and that the aconitine-induced tachyarrhythmia is augmented by the beta 1 -adrenergic action of higenamines.
The relaxation effect and mechanism of action of higenamine in the rat corpus cavernosum
The results suggest that higenamine may be valuable as a new lead compound for treating erectile dysfunction and may be mediated through β-adrenoceptors.
Biphasic tracheal relaxation induced by higenamine and nantenine from Nandina domestica Thunberg.
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Higenamine alleviates cerebral ischemia-reperfusion injury in rats.
Higenamine improved functional state of nerves, significantly inhibited the I/R-induced increase in the serum level of tumor necrosis factor α (TNF-alpha) and interleukins (ILs) such as IL-1, IL-6 and IL-18, and CD14+ cells, while decreasing the axonal nerve degeneration.
Author ’ s Accepted Manuscript Applications of Higenamine in parmacology and medicine
Higenamine, a plant-based alkaloid, was initially isolated from Aconitum and identified as the active cardiotonic component of AconItum and has been tested as a candidate of pharmacologic stress agent in the detection of coronary artery diseases (CADs) and now researchers have just accomplished the phase III clinical studies successfully in China.
Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine.
A monographic overview on (S)-norcoclaurine (NC) alkaloid from three diverse points of view, collected all together for the first time: the synthetic one, where the compound is seen as a target chiral molecule to be obtained in the highest optical purity and as a starting point for the development of biocatalytic asymmetric syntheses of tetrahydroisoquinoline alkaloids.
Norcoclaurine Synthase: Mechanism of an Enantioselective Pictet-Spengler Catalyzing Enzyme
Kinetic and crystallographic data suggest that the reaction mechanism of norcoclaurine synthase occurs according to a typical bifunctional catalytic process, which may offer the advantage of a clean and green synthetic process in the absence of organic solvents and metal catalysts.