Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells.

@article{Berkovic1995EffectsOH,
  title={Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells.},
  author={D. Berkovic and U. Grunwald and W. Menzel and C. Unger and W. Hiddemann and E. Fleer},
  journal={European journal of cancer},
  year={1995},
  volume={31A 12},
  pages={
          2080-5
        }
}
Hexadecylphosphocholine (HePC) is an analogue of the antiproliferative alkyllysophospholipids (ALP). As these lipid-like compounds interfere with membrane lipid metabolism at several sites, we studied the effects of HePC on uptake and metabolism of inositol and choline, two important phospholipid precursor molecules in two sensitive cell lines, Raji and KB, and in a resistant variant of KB cells, KBr. HePC substantially inhibited the membrane uptake of inositol and of choline in KB and Raji… Expand
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