Effects of hexadecylphosphocholine on phosphatidylcholine and phosphatidylserine metabolism in human lymphoma cells.

@article{Berkovic2002EffectsOH,
  title={Effects of hexadecylphosphocholine on phosphatidylcholine and phosphatidylserine metabolism in human lymphoma cells.},
  author={D. Berkovic and Sabine Sievers and D. Haase and E. Fleer and C. Binder},
  journal={Journal of experimental therapeutics & oncology},
  year={2002},
  volume={2 2},
  pages={
          85-92
        }
}
Hexadecylphosphocholine (HePC) belongs to a new group of antineoplastic agents, the alkylphosphocholines (APC). HePC shows a broad spectrum of biological effects in various cells in vitro and in vivo. It has pronounced antiproliferative effects on neoplastic cells. The molecular mechanism by which HePC exerts its biological effects is still under investigation. By generating a HePC-resistant cell variant of the lymphoma cell line Raji, we established a model to investigate which molecular… Expand
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