Effects of hepatocyte nuclear factor-4alpha on the regulation of the hepatic acute phase response.

@article{Wang2007EffectsOH,
  title={Effects of hepatocyte nuclear factor-4alpha on the regulation of the hepatic acute phase response.},
  author={Zhongyan Wang and Peter Ashley Burke},
  journal={Journal of molecular biology},
  year={2007},
  volume={371 2},
  pages={323-35}
}
Following injury, a large number of hepatic acute phase genes are rapidly modulated at the transcriptional level to restore metabolic homeostasis and limit tissue damage. Hepatocyte nuclear factor 4alpha (HNF-4alpha) is a liver-enriched transcription factor that controls embryonic liver development and regulates tissue-specific gene expression in adult liver cells. Many genes encoding acute phase proteins contain HNF-4alpha-binding sites in their promoter regions and are transcriptionally… CONTINUE READING

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