Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility.

@article{Yesilaltay2006EffectsOH,
  title={Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility.},
  author={Ayce Yesilaltay and Mar{\'i}a Gabriela Morales and L Pi{\~n}eiro Amigo and Silvana Zanlungo and Attilio A Rigotti and Sharon L Karackattu and Mary H. Donahee and Karen F. Kozarsky and Monty Krieger},
  journal={Endocrinology},
  year={2006},
  volume={147 4},
  pages={1577-88}
}
The etiology of human female infertility is often uncertain. The sterility of high-density lipoprotein (HDL) receptor-negative (SR-BI(-/-)) female mice suggests a link between female infertility and abnormal lipoprotein metabolism. SR-BI(-/-) mice exhibit elevated plasma total cholesterol [with normal-sized and abnormally large HDL and high unesterified to total plasma cholesterol (UC:TC) ratio]. We explored the influence of hepatic SR-BI on female fertility by inducing hepatic SR-BI expression… CONTINUE READING
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