Effects of hepatic P-450 enzyme inhibitors and inducers on the duration of xylazine + ketamine anesthesia in broiler chickens and mice.

@article{Roder1993EffectsOH,
  title={Effects of hepatic P-450 enzyme inhibitors and inducers on the duration of xylazine + ketamine anesthesia in broiler chickens and mice.},
  author={J. D. Roder and R Akkaya and Hamid R Amouzadeh and Subbiah Sangiah and Gillian Burrows and Charles W Qualls},
  journal={Veterinary and human toxicology},
  year={1993},
  volume={35 2},
  pages={116-8}
}
We previously showed that pretreatment with inhibitors of hepatic P-450 microsomal enzymes prolonged xylazine-ketamine anesthesia, which sometimes led to mortality in rats. In this study we determined if similar effects were produced in broiler chickens and mice. A combination of 5 mg xylazine/kg and 15 mg ketamine/kg im was given to broiler chickens 5-6 w… CONTINUE READING