Effects of hemodialysis on protein metabolism.

  title={Effects of hemodialysis on protein metabolism.},
  author={Talat Alp Ikizler},
  journal={Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation},
  volume={15 1},
  • T. Ikizler
  • Published 2005
  • Biology, Medicine
  • Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
Uremic malnutrition, as evidenced by decreased muscle mass, is strongly associated with increased risk of death and hospitalization events in chronic hemodialysis (CHD) patients. Several factors that influence protein metabolism predispose CHD patients to increased catabolism and loss of lean body mass. It has been long suspected that the hemodialysis (HD) procedure is a net catabolic event. Recent studies show that the HD procedure indeed induces a net protein catabolic state at the whole-body… 

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  • J. Bergström
  • Medicine
    Journal of the American Society of Nephrology : JASN
  • 1995
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Protein catabolic factors in patients on renal replacement therapy.

Signs of malnutrition in regular dialysis patients are reduced muscle mass assessed by anthropometric methods, low concentration of albumin, transferrin, and other liver-derived proteins, low alkali-soluble protein in muscle in relation to dry fat-free weight and DNA, abnormal plasma amino acid and intracellular amino acid profiles, similar to those found in untreated uremia, indicating that dialysis does not reverse these abnormalities.

Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation.

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    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1993

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Malnutrition in hemodialysis patients.

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Effect of nutrition on morbidity and mortality in maintenance dialysis patients.

  • J. Kopple
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    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1994