Effects of harringtonine in combination with acivicin, adriamycin, L-asparaginase, cytosine arabinoside, dexamethasone, fluorouracil or methotrexate on human acute myelogenous leukemia cell line KG-1

@article{Okano1983EffectsOH,
  title={Effects of harringtonine in combination with acivicin, adriamycin, L-asparaginase, cytosine arabinoside, dexamethasone, fluorouracil or methotrexate on human acute myelogenous leukemia cell line KG-1},
  author={Tsuyoshi Okano and Dr. Takao Ohnuma and James F. Holland and H Phillip Koeffler and Han Jui},
  journal={Investigational New Drugs},
  year={1983},
  volume={1},
  pages={145-150}
}
Harringtonine (HT) is a new antitumor agent reported to be active in patients with leukemia and lymphoma. The interaction of HT with various antitumor agents was studied in vitro using a human acute myelogenous leukemia cell line KG-1. For the analysis of the drug-drug interaction at the cellular level, Steel proposed the concept of an envelope of additivity. Using this concept, the effect of a two drug combination can be classified as supraadditive (enhancement of the effect), non-interactive… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Therapeutic synergism of homoharring - tonine plus 5 - fluorouracil against leukemia P 388 ( P 388 / 0 ) and araC resistant P 388 ( P 388 / AraC )

WR Laster, MW Trader, FM Schabel, TH Corbett, DP Girsward
( Abstract ) Proc Am Assoc Cancer Res • 1982

Therapeutic synergism of homoharringtonine plus 5-fluorouracil against leukemia P388 (P388/0) and ara-C resistant P388 (P388/Ara-C). (Abstract

WR Laster, MW Trader, FM JrSchabel, TH Corbett, DP JrGirsward
Proc Am Assoc Cancer Res • 1982
View 1 Excerpt

Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity.

International journal of radiation oncology, biology, physics • 1979
View 2 Excerpts

Terminology in the description of drug-radiation interactions.

International journal of radiation oncology, biology, physics • 1979
View 2 Excerpts

Chinese People ' s Liberation Army 187 th Hospital : Har - ringtonine in acute leukemias . Clinical analysis of 31 cases

GG Steel
Chin Med J • 1977

The antitumor effects and pharmacologic actions of har - ringtonine

RG Powell, D Weisleder, CR Smith, IH Wolff
Chin Med J • 1977

Improvement in the therapeutic index of methotrexate (NSC-740) by L-asparaginase (NSC109229)

RL Capizzi
Cancer Chemotherap Rep (Part • 1975
View 1 Excerpt

Similar Papers

Loading similar papers…