Effects of harmine on dopamine output and metabolism in rat striatum: role of monoamine oxidase-A inhibition

@article{Iurlo2001EffectsOH,
  title={Effects of harmine on dopamine output and metabolism in rat striatum: role of monoamine oxidase-A inhibition},
  author={Matteo Iurlo and M. Leone and Bj{\"o}rn Schilstr{\"o}m and Love Linn{\'e}r and George Nomikos and Peter Hertel and Bruno Silvestrini and Tor Svensson},
  journal={Psychopharmacology},
  year={2001},
  volume={159},
  pages={98-104}
}
In vivo microdialysis was used to investigate the effects of acute injections of harmine on extracellular concentrations of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxindoleacetic acid (5-HIAA) in the striatum of awake rats. Administration of harmine in doses of 0.5, 2.5, and 10 mg/kg (i.p.) elicited a dose-dependent increase of the dopamine efflux to 152, 173, and 243% and a decrease in DOPAC to 52, 36, and 10%, and HVA to 67, 45, and 20% throughout… CONTINUE READING