Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.

Abstract

BACKGROUND Haptoglobin (Hp) is a haemoglobin-binding protein with immunomodulatory properties. Its gene (16q22) harbours a common polymorphism with two different alleles: Hp1 and Hp2. Genotype Hp22 has been shown to be over-represented in different immune diseases. Results in Crohn's disease (CD) are contradictory. AIMS To determine whether Hp plays a… (More)
DOI: 10.1136/gut.2011.240978

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Cite this paper

@article{Marquez2012EffectsOH, title={Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.}, author={L. PadroL. Marquez and C. -L. Shen and Isabelle Cleynen and Gert de Hertogh and Kristel van Steen and Kathleen Machiels and Cl{\'e}mentine Perrier and Vera Ballet and Sophie Organe and M Ferrante and Liesbet Henckaerts and Gonzalo Galicia and Paul J. Rutgeerts and J. L. Ceuppens and S{\'e}verine Vermeire}, journal={Gut}, year={2012}, volume={61 4}, pages={528-34} }