The effects of handedness on the movement-related changes in beta rhythms (14-30 Hz) in the left and right perirolandic area were analyzed in 12 right-handed and 11 left-handed subjects. The motor task consisted of unilateral brisk or slow self-paced extension of the right or left index finger. The handedness effects were as follows. First, in both handedness groups, the premovement desynchronization of beta rhythms at both hemispheres was greatest before slow movement of the "nondominant" finger, especially at electrodes presumably overlying the MI areas. Second, the lefthanded group showed less desynchronization in both hemispheres during execution of a slow movement than the righthanded group. Third, the postmovement beta synchronization showed a contralateral preponderance which was greater after movements of the nondominant than the "dominant" finger in the righthanded group and was equal for both fingers in the lefthanded group. The results suggest that handedness effects on movement-related changes in central beta rhythms are coupled to movements of the nondominant finger and that their manifestation differs in the pre- and postmovement periods.