Effects of halothane on transmembrane potentials, Ca2+ transients, and papillary muscle tension in the cat.

@article{Bosnjak1986EffectsOH,
  title={Effects of halothane on transmembrane potentials, Ca2+ transients, and papillary muscle tension in the cat.},
  author={Zeljko J Bosnjak and John P. Kampine},
  journal={The American journal of physiology},
  year={1986},
  volume={251 2 Pt 2},
  pages={
          H374-81
        }
}
The effects of halothane on cat papillary muscle were studied in vitro at different pacing rates (60, 75, 100, and 150 beats/min). Simultaneous measurements of transmembrane potentials, intracellular Ca2+ transients, and isometric tension were made before and after introduction of 1 and 2 minimal alveolar concentration halothane. Anesthetic concentrations in the superfusion bath were measured using a gas chromatography procedure. The Ca2+-sensitive photoprotein, aequorin, was microinjected into… CONTINUE READING

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