Effects of halothane on platelet function.

Human platelets in platelet rich plasma (PRP) incubated at 37 degrees C with 0.3-2% halothane for 5-10 min lost the ability to aggregate with ADP, epinephrine and collagen. At the same time uptake and release of 14C-serotonin was inhibited. When halothane supply was removed, platelet functions rapidly returned to normal. However, after high concentrations… CONTINUE READING