Effects of halothane on membrane currents associated with contraction in single myocytes isolated from guinea-pig ventricle.

@article{Terrar1988EffectsOH,
  title={Effects of halothane on membrane currents associated with contraction in single myocytes isolated from guinea-pig ventricle.},
  author={Derek A. Terrar and J G Victory},
  journal={British journal of pharmacology},
  year={1988},
  volume={94 2},
  pages={
          500-8
        }
}
1. The effects of halothane on electrical activity and contraction were investigated in single myocytes isolated from guinea-pig ventricle. 2. Halothane depressed the plateau and shortened the duration of action potentials. 3. Halothane also reduced the amplitude of inward calcium currents and of additional inward current activated by cytosolic calcium under voltage-clamp conditions. 4. Contractions (measured by an optical technique) accompanying either action potentials or calcium currents… CONTINUE READING

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