Effects of halothane and methoxyflurane on the hypothalamic-pituitary-adrenal axis in rat

@article{Karuri1998EffectsOH,
  title={Effects of halothane and methoxyflurane on the hypothalamic-pituitary-adrenal axis in rat},
  author={A. R. Karuri and L. Engelking and M. S. Kumar},
  journal={Brain Research Bulletin},
  year={1998},
  volume={47},
  pages={205-209}
}
  • A. R. Karuri, L. Engelking, M. S. Kumar
  • Published 1998
  • Biology, Medicine
  • Brain Research Bulletin
  • Effects of acute exposure (2 h) to either 1.5% halothane or 0.5% methoxyflurane on chemical mediators of the hypothalamic-pituitary-adrenal (HPA) axis were evaluated in male Sprague-Dawley rats immediately after exposure, after the righting reflex (4 h), or 24 h postexposure. Effects of these anesthetics on hippocampal corticotropin releasing factor (CRF) were also evaluated. Methoxyflurane caused significant elevations in pituitary adrenocorticotropin hormone (ACTH)-like immunoreactivities in… CONTINUE READING

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