Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channels.

@article{Stadnicka1999EffectsOH,
  title={Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channels.},
  author={Anna Stadnicka and Wai Meng Kwok and Hali A. Hartmann and Zeljko J Bosnjak},
  journal={Anesthesiology},
  year={1999},
  volume={90 6},
  pages={
          1671-83
        }
}
BACKGROUND Cloning and heterologous expression of ion channels allow biophysical and molecular studies of the mechanisms of volatile anesthetic interactions with human heart sodium channels. Volatile anesthetics may influence the development of arrhythmias arising from cardiac sodium channel dysfunction. For that reason, understanding the mechanisms of interactions between these anesthetics and cardiac sodium channels is important. This study evaluated the mechanisms of volatile anesthetic… CONTINUE READING
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