Effects of haloperidol and low dose clozapine on the acetylcholine turnover rate in rat forebrain structures.

Abstract

The contents of acetylcholine and choline as well as the acetylcholine turnover rates were measured in olfactory tubercle, nucleus accumbens and striatum of rats receiving haloperidol and low dose clozapine intraperitoneally. Both haloperidol (1 mg/kg) and clozapine (1.25 mg/kg) led to an increase in the acetylcholine turnover in the mesolimbic nucleus… (More)

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