Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes.

@article{Lalibert1998EffectsOG,
  title={Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes.},
  author={Jos{\'e}e Lalibert{\'e} and Adelinda Yee and Y Xiong and Beverly S. Mitchell},
  journal={Blood},
  year={1998},
  volume={91 8},
  pages={2896-904}
}
Depletion of guanine nucleotide pools after inhibition of inosine monophosphate dehydrogenase (IMPDH) potently inhibits DNA synthesis by arresting cells in G1 and has been shown to induce the differentiation of cultured myeloid and erythroid cell lines, as well as chronic granulocytic leukemic cells after blast transformation. Inhibitors of IMPDH are also highly effective as immunosuppressive agents. The mechanism underlying these pleiotropic effects of depletion of guanine nucleotides is… CONTINUE READING

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