Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels.

@article{Grfte1998EffectsOG,
  title={Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels.},
  author={Thorbj\orn Gr\ofte and Dorthe Svenstrup Jensen and Henning Gr\onb{\ae}k and Troels Wolthers and S\oren Astrup Jensen and Niels Tygstrup and Hendrik Vilstrup},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1998},
  volume={275 1},
  pages={E79-E86}
}
Growth hormone (GH) reduces the catabolic side effects of steroid treatment due to its effects on tissue protein synthesis/degradation. Little attention is focused on hepatic amino acid degradation and urea synthesis. Five groups of rats were given 1) placebo, 2) prednisolone, 3) placebo, pair fed to the steroid group, 4) GH, and 5) prednisolone and GH. After 7 days, the in vivo capacity of urea N synthesis (CUNS) was determined by saturating alanine infusion, in parallel with measurements of… CONTINUE READING