Effects of growth hormone on fuel utilization and muscle glycogen synthase activity in normal humans.

@article{Bak1991EffectsOG,
  title={Effects of growth hormone on fuel utilization and muscle glycogen synthase activity in normal humans.},
  author={Jens Friis Bak and Niels Peter Hundahl M\oller and Oliver Schmitz},
  journal={The American journal of physiology},
  year={1991},
  volume={260 5 Pt 1},
  pages={E736-42}
}
To examine the insulin antagonistic effects of growth hormone (GH), seven healthy subjects underwent, in random order, two 5-h euglycemic clamp studies with moderate hyperinsulinemia. A GH infusion (45 ng.kg-1.min-1) was given throughout one of the studies. GH inhibited the insulin-stimulated glucose disposal by 27% from 4.4 +/- 0.7 to 3.3 +/- 0.4 mg.kg-1.min-1 (P less than 0.02) and raised the nonprotein energy expenditures (NPEE) from 18.7 +/- 0.5 to 20.5 +/- 0.3 kcal.kg-1.24 h-1 (P less than… CONTINUE READING