Effects of grapefruit juice on the stereoselective disposition of nicardipine in humans: evidence for dominant presystemic elimination at the gut site

@article{Uno2000EffectsOG,
  title={Effects of grapefruit juice on the stereoselective disposition of nicardipine in humans: evidence for dominant presystemic elimination at the gut site},
  author={Tsukasa Uno and Tadashi Ohkubo and Kazunobu Sugawara and Akihiro Higashiyama and Shigeru Motomura and Takashi Ishizaki},
  journal={European Journal of Clinical Pharmacology},
  year={2000},
  volume={56},
  pages={643-649}
}
Abstract. Objectives: To assess relative roles of the intestinal and hepatic stereoselective metabolism of nicardipine in an oral first-pass disposal with and without grapefruit juice intake. Methods: The kinetic profiles of (+)- and (–)-nicardipine were studied in the six normal healthy male volunteers who received oral (40 mg) and intravenous (2 mg) racemic nicardipine, first with water and second with grapefruit juice. Both the enantiomers were determined by the stereoselective high… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Reduced prehepatic extraction of nicardipine in the presence of pioglitazone in rats.

  • The Journal of pharmacy and pharmacology
  • 2008
VIEW 5 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED